| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 05-02-21 20:00 | Albacete Balompie | RCD Mallorca | 0:1 |
| 06-02-21 15:00 | FC Cartagena | Real Oviedo | 2:0 |
| 06-02-21 17:15 | UD Logroñés | Sporting Gijón | 0:4 |
| 06-02-21 19:30 | CF Fuenlabrada | UD Almeria | 1:1 |
| 07-02-21 13:00 | FC Girona | CD Leganés | 0:2 |
| 07-02-21 15:00 | FC Málaga | Real Zaragoza | 1:2 |
| 07-02-21 17:15 | CD Castellón | CD Mirandés | 0:1 |
| 07-02-21 17:15 | Rayo Vallecano | CD Teneriffa | 0:1 |
| 07-02-21 19:30 | UD Las Palmas | CD Sabadell | 0:1 |
| 08-02-21 18:00 | SD Ponferradina | AD Alcorcón | 2:0 |
| 08-02-21 20:00 | CD Lugo | Espanyol Barcelona | 1:1 |