| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 22-01-21 18:00 | CF Fuenlabrada | AD Alcorcón | 0:0 |
| 22-01-21 20:00 | Albacete Balompie | Real Zaragoza | 1:0 |
| 23-01-21 15:00 | Rayo Vallecano | RCD Mallorca | 1:3 |
| 23-01-21 17:15 | CD Lugo | CD Teneriffa | 2:0 |
| 23-01-21 17:15 | FC Girona | Espanyol Barcelona | 1:0 |
| 23-01-21 19:30 | FC Málaga | SD Ponferradina | 0:2 |
| 24-01-21 13:00 | UD Almeria | CD Sabadell | 2:2 |
| 24-01-21 15:00 | UD Logroñés | Real Oviedo | 0:0 |
| 24-01-21 17:15 | CD Castellón | Sporting Gijón | 2:0 |
| 24-01-21 19:30 | UD Las Palmas | CD Leganés | 2:1 |
| 25-01-21 20:00 | FC Cartagena | CD Mirandés | 0:2 |