| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 08-01-21 20:00 | Real Zaragoza | UD Logroñés | 2:0 |
| 09-01-21 17:15 | FC Málaga | Real Oviedo | 1:1 |
| 10-01-21 15:00 | RCD Mallorca | UD Las Palmas | 0:1 |
| 10-01-21 17:15 | CD Teneriffa | FC Cartagena | 3:0 |
| 10-01-21 20:00 | Espanyol Barcelona | CD Castellón | 2:0 |
| 11-01-21 18:00 | SD Ponferradina | FC Girona | 1:1 |
| 11-01-21 19:30 | Sporting Gijón | CF Fuenlabrada | 2:1 |
| 11-01-21 20:30 | CD Sabadell | CD Lugo | 1:1 |
| 19-01-21 18:00 | CD Mirandés | Rayo Vallecano | 0:2 |
| 26-01-21 18:00 | AD Alcorcón | Albacete Balompie | 1:2 |
| 17-02-21 18:00 | CD Leganés | UD Almeria | 2:1 |