| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-01-21 13:00 | CF Fuenlabrada | CD Leganés | 0:0 |
| 02-01-21 15:00 | Rayo Vallecano | AD Alcorcón | 2:1 |
| 02-01-21 17:15 | UD Logroñés | CD Mirandés | 2:1 |
| 02-01-21 19:30 | FC Cartagena | Real Zaragoza | 1:1 |
| 03-01-21 13:00 | CD Castellón | CD Teneriffa | 0:1 |
| 03-01-21 15:00 | UD Las Palmas | Espanyol Barcelona | 1:0 |
| 03-01-21 17:15 | Albacete Balompie | FC Málaga | 1:1 |
| 03-01-21 19:30 | UD Almeria | SD Ponferradina | 3:1 |
| 03-01-21 20:00 | Real Oviedo | RCD Mallorca | 2:2 |
| 04-01-21 17:30 | FC Girona | CD Sabadell | 0:0 |
| 04-01-21 20:00 | CD Lugo | Sporting Gijón | 0:0 |