| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 01-10-22 1:00 | Puebla FC | CF America | 1:2 |
| 01-10-22 3:00 | FC Juarez | UNAM Pumas | 3:1 |
| 01-10-22 23:00 | San Luis | Tigres de UANL | 0:3 |
| 01-10-22 23:05 | CF Monterrey | CF Pachuca | 0:0 |
| 02-10-22 1:05 | Atlas Guadalajara | CID Necaxa | 1:0 |
| 02-10-22 3:05 | CD Cruz Azul | Deportivo Guadalajara | 2:1 |
| 02-10-22 18:00 | Deportivo Toluca | Queretaro F.C. | 4:1 |
| 03-10-22 0:05 | Santos Laguna | Mazatlán FC | 3:0 |
| 03-10-22 2:00 | Club Leon | Club Tijuana | 2:2 |