| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 17-09-22 1:00 | Puebla FC | Tigres de UANL | 2:1 |
| 17-09-22 3:00 | Mazatlán FC | Deportivo Toluca | 1:1 |
| 18-09-22 1:05 | CF Monterrey | Atlas Guadalajara | 2:0 |
| 18-09-22 2:00 | CF America | Deportivo Guadalajara | 2:1 |
| 18-09-22 23:00 | UNAM Pumas | CD Cruz Azul | 1:2 |
| 19-09-22 1:05 | Santos Laguna | FC Juarez | 2:0 |
| 19-09-22 1:05 | Club Leon | Queretaro F.C. | 3:1 |
| 19-09-22 3:00 | San Luis | CF Pachuca | 1:2 |
| 19-09-22 3:05 | Club Tijuana | CID Necaxa | 1:1 |