| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 07-09-22 1:00 | Club Leon | FC Juarez | 1:0 |
| 07-09-22 1:05 | Santos Laguna | CID Necaxa | 3:1 |
| 07-09-22 3:05 | CF Monterrey | CD Cruz Azul | 3:2 |
| 07-09-22 3:05 | CF America | San Luis | 3:0 |
| 08-09-22 1:00 | Tigres de UANL | Deportivo Toluca | 3:1 |
| 08-09-22 1:00 | Puebla FC | CF Pachuca | 2:2 |
| 08-09-22 3:00 | Mazatlán FC | Atlas Guadalajara | 1:0 |
| 08-09-22 3:05 | UNAM Pumas | Queretaro F.C. | 4:1 |
| 08-09-22 3:05 | Club Tijuana | Deportivo Guadalajara | 1:2 |