| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 25-09-10 12:45 | Manchester City | FC Chelsea | 1:0 |
| 25-09-10 15:00 | FC Arsenal | West Bromwich Albion | 2:3 |
| 25-09-10 15:00 | Birmingham City | Wigan Athletic | 0:0 |
| 25-09-10 15:00 | FC Blackpool | Blackburn Rovers | 1:2 |
| 25-09-10 15:00 | FC Fulham | FC Everton | 0:0 |
| 25-09-10 15:00 | FC Liverpool | AFC Sunderland | 2:2 |
| 25-09-10 15:00 | West Ham United | Tottenham Hotspurs | 1:0 |
| 26-09-10 12:00 | Bolton Wanderers | Manchester United | 2:2 |
| 26-09-10 14:05 | Wolverhampton Wanderers | Aston Villa | 1:2 |
| 26-09-10 16:10 | Newcastle United | FC Stoke City | 1:2 |