| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-09-10 12:45 | FC Stoke City | West Ham United | 1:1 |
| 18-09-10 15:00 | Aston Villa | Bolton Wanderers | 1:1 |
| 18-09-10 15:00 | Blackburn Rovers | FC Fulham | 1:1 |
| 18-09-10 15:00 | FC Everton | Newcastle United | 0:1 |
| 18-09-10 15:00 | Tottenham Hotspurs | Wolverhampton Wanderers | 3:1 |
| 18-09-10 15:00 | West Bromwich Albion | Birmingham City | 3:1 |
| 18-09-10 17:30 | AFC Sunderland | FC Arsenal | 1:1 |
| 19-09-10 13:30 | Manchester United | FC Liverpool | 3:2 |
| 19-09-10 15:00 | Wigan Athletic | Manchester City | 0:2 |
| 19-09-10 16:00 | FC Chelsea | FC Blackpool | 4:0 |