| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 28-08-10 12:45 | Blackburn Rovers | FC Arsenal | 1:2 |
| 28-08-10 15:00 | FC Blackpool | FC Fulham | 2:2 |
| 28-08-10 15:00 | FC Chelsea | FC Stoke City | 2:0 |
| 28-08-10 15:00 | Tottenham Hotspurs | Wigan Athletic | 0:1 |
| 28-08-10 15:00 | Wolverhampton Wanderers | Newcastle United | 1:1 |
| 28-08-10 17:30 | Manchester United | West Ham United | 3:0 |
| 29-08-10 13:30 | Bolton Wanderers | Birmingham City | 2:2 |
| 29-08-10 15:00 | FC Liverpool | West Bromwich Albion | 1:0 |
| 29-08-10 15:00 | AFC Sunderland | Manchester City | 1:0 |
| 29-08-10 16:00 | Aston Villa | FC Everton | 1:0 |