| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-08-10 15:00 | FC Arsenal | FC Blackpool | 6:0 |
| 21-08-10 15:00 | Birmingham City | Blackburn Rovers | 2:1 |
| 21-08-10 15:00 | FC Everton | Wolverhampton Wanderers | 1:1 |
| 21-08-10 15:00 | FC Stoke City | Tottenham Hotspurs | 1:2 |
| 21-08-10 15:00 | West Bromwich Albion | AFC Sunderland | 1:0 |
| 21-08-10 15:00 | West Ham United | Bolton Wanderers | 1:3 |
| 21-08-10 17:15 | Wigan Athletic | FC Chelsea | 0:6 |
| 22-08-10 13:30 | Newcastle United | Aston Villa | 6:0 |
| 22-08-10 16:00 | FC Fulham | Manchester United | 2:2 |
| 23-08-10 20:00 | Manchester City | FC Liverpool | 3:0 |