| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 09-11-10 19:45 | FC Stoke City | Birmingham City | 3:2 |
| 09-11-10 20:00 | Tottenham Hotspurs | AFC Sunderland | 1:1 |
| 10-11-10 19:45 | West Ham United | West Bromwich Albion | 2:2 |
| 10-11-10 19:45 | Wigan Athletic | FC Liverpool | 1:1 |
| 10-11-10 19:45 | Wolverhampton Wanderers | FC Arsenal | 0:2 |
| 10-11-10 19:45 | Aston Villa | FC Blackpool | 3:2 |
| 10-11-10 19:45 | FC Chelsea | FC Fulham | 1:0 |
| 10-11-10 19:45 | Newcastle United | Blackburn Rovers | 1:2 |
| 10-11-10 20:00 | FC Everton | Bolton Wanderers | 1:1 |
| 10-11-10 20:00 | Manchester City | Manchester United | 0:0 |