| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 24-02-22 17:45 | Olympiakos Pireu | Atalanta Bergamo | 0:3 |
| 24-02-22 17:45 | Lazio Roma | FC Porto | 2:2 |
| 24-02-22 17:45 | Real Sociedad | RB Leipzig | 1:3 |
| 24-02-22 17:45 | Dínamo Zagreb | FC Sevilla | 1:0 |
| 24-02-22 20:00 | Sporting Braga | Sheriff Tiraspol | 5:2a.pen. |
| 24-02-22 20:00 | Glasgow Rangers | Borussia Dortmund | 2:2 |
| 24-02-22 20:00 | SSC Nápoles | FC Barcelona | 2:4 |
| 24-02-22 20:00 | Real Betis Sevilla | Zenit S.Petersburgo | 0:0 |