| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 17-02-22 17:45 | Borussia Dortmund | Glasgow Rangers | 2:4 |
| 17-02-22 17:45 | Zenit S.Petersburgo | Real Betis Sevilla | 2:3 |
| 17-02-22 17:45 | Sheriff Tiraspol | Sporting Braga | 2:0 |
| 17-02-22 17:45 | FC Barcelona | SSC Nápoles | 1:1 |
| 17-02-22 20:00 | FC Porto | Lazio Roma | 2:1 |
| 17-02-22 20:00 | Atalanta Bergamo | Olympiakos Pireu | 2:1 |
| 17-02-22 20:00 | FC Sevilla | Dínamo Zagreb | 3:1 |
| 17-02-22 20:00 | RB Leipzig | Real Sociedad | 2:2 |