| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 04-12-18 18:30 | FC Getafe | Cordóba CF | 5:1 |
| 04-12-18 18:30 | FC Valencia | CD Ebro | 1:0 |
| 04-12-18 19:30 | Rayo Vallecano | CD Leganés | 0:1 |
| 04-12-18 20:30 | Espanyol Barcelona | FC Cádiz | 1:0 |
| 05-12-18 18:30 | FC Girona | Deportivo Alavés | 2:1 |
| 05-12-18 18:30 | Atlético Madrid | UE Sant Andreu | 4:0 |
| 05-12-18 19:30 | Real Sociedad | Celta Vigo | 2:0 |
| 05-12-18 19:30 | FC Villarreal | UD Almeria | 8:0 |
| 05-12-18 19:30 | FC Sevilla | CF Villanovense | 1:0 |
| 05-12-18 20:30 | Real Valladolid | RCD Mallorca | 2:1 |
| 05-12-18 20:30 | FC Barcelona | CyD Leonesa | 4:1 |
| 06-12-18 11:00 | UD Levante | CD Lugo | 2:0 |
| 06-12-18 15:15 | Real Madrid | UD Melilla | 6:1 |
| 06-12-18 17:30 | SD Huesca | Athletic Bilbao | 0:4 |
| 06-12-18 17:30 | SD Eibar | Sporting Gijón | 2:2 |
| 06-12-18 19:45 | Real Betis Sevilla | Racing Santander | 4:0 |