| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 16-10-18 19:00 | FC Elche | Cordóba CF | 1:4 |
| 17-10-18 16:00 | CD Ebro | Club Lleida Esportiu | 2:1 |
| 17-10-18 19:00 | CD Lugo | AD Alcorcón | 1:0 |
| 17-10-18 19:15 | Union Mutilvera | CF Villanovense | 1:3 |
| 17-10-18 19:30 | Racing Santander | UD Logroñés | 1:0 |
| 17-10-18 19:30 | UE Sant Andreu | CD Calahorra | 1:0a.p. |
| 17-10-18 19:45 | UD Melilla | Ontinyent CF | 2:0 |
| 17-10-18 19:45 | La Hoya Lorca | CyD Leonesa | 0:3 |
| 17-10-18 20:00 | Real Zaragoza | FC Cádiz | 0:1 |
| 18-10-18 19:00 | CF Rayo Majadahonda | Sporting Gijón | 4:5a.pen. |
| 18-10-18 20:00 | UD Almeria | CF Reús Deportiu | 3:1 |