| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-09-18 17:45 | RCD Mallorca | Real Oviedo | 1:0 |
| 11-09-18 17:45 | FC Málaga | UD Almeria | 1:2 |
| 12-09-18 17:00 | CD Ebro | Real Murcia C. F. | 5:4a.pen. |
| 12-09-18 18:30 | Ontinyent CF | Real Jaén C.F. | 7:6a.pen. |
| 12-09-18 19:00 | CA Osasuna | CF Reús Deportiu | 1:2 |
| 12-09-18 19:00 | AD Alcorcón | UD Extremadura | 1:0 |
| 12-09-18 19:00 | UCAM Múrcia | Racing Santander | 0:2 |
| 12-09-18 19:00 | Club Lleida Esportiu | SD Compostela | 1:0 |
| 12-09-18 19:30 | CD Calahorra | CD Castellón | 2:0 |
| 12-09-18 19:30 | UE Sant Andreu | SD Gernika Club | 1:0a.p. |
| 12-09-18 19:30 | CyD Leonesa | CF Fuenlabrada | 6:5a.pen. |
| 12-09-18 19:45 | CF Villanovense | CF Badalona | 2:1 |
| 12-09-18 19:45 | La Hoya Lorca | Unionistas CF | 2:1a.p. |
| 12-09-18 19:45 | UD Melilla | CD Tudelano | 3:0 |
| 12-09-18 20:00 | Real Zaragoza | Deportivo La Coruña | 2:1 |
| 12-09-18 20:00 | FC Cartagena | UD Logroñés | 5:6a.pen. |
| 12-09-18 21:00 | CD Teneriffa | FC Cádiz | 1:2 |
| 12-09-18 21:00 | Cordóba CF | Gimnástic de Tarragona | 2:0 |
| 13-09-18 19:00 | Albacete Balompie | CD Lugo | 2:3 |
| 13-09-18 19:00 | CD Numancia | Sporting Gijón | 1:2 |
| 13-09-18 21:00 | FC Elche | FC Granada | 2:1 |
| 13-09-18 21:00 | UD Las Palmas | CF Rayo Majadahonda | 1:2 |