| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 23-10-25 17:45 | AZ Alkmaar | SK Slovan Bratislava | 1:0 |
| 23-10-25 17:45 | Shaktiar Donetsk | Legia Varsóvia | 1:2 |
| 23-10-25 17:45 | Racing Club Estrasburgo | Jagiellonia Bialystok | 1:1 |
| 23-10-25 17:45 | AEK Atenas | FC Aberdeen | 6:0 |
| 23-10-25 17:45 | Breidablik Kopavogur | Kuopion PS | 0:0 |
| 23-10-25 17:45 | KF Shkendija | FC Shelbourne | 1:0 |
| 23-10-25 17:45 | BK Häcken | Rayo Vallecano | 2:2 |
| 23-10-25 17:45 | KF Drita Gjilan | Omonia Nicosia | 1:1 |
| 23-10-25 17:45 | SK Rapid Vienna | AC Fiorentina | 0:3 |
| 23-10-25 20:00 | Crystal Palace | AEK Larnaca | 0:1 |
| 23-10-25 20:00 | Shamrock Rovers | NK Celje | 0:2 |
| 23-10-25 20:00 | FSV Mainz 05 | HŠK Zrinjski Mostar | 1:0 |
| 23-10-25 20:00 | Lincoln Red Imps FC | Lech Poznan | 2:1 |
| 23-10-25 20:00 | Sigma Olomouc | KS Rakow Czestochowa | 1:1 |
| 23-10-25 20:00 | Samsunspor | Dínamo Kiev | 3:0 |
| 23-10-25 20:00 | Universitatea Craiova | FC Noah | 1:1 |
| 23-10-25 20:00 | Hamrun Spartans | FC Lausanne-Sport | 0:1 |
| 24-10-25 15:00 | HNK Rijeka | Sparta Praga | 1:0 |