| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 23-09-25 16:00 | Cagliari Calcio | Frosinone Calcio | 4:1 |
| 23-09-25 17:30 | Udinese Calcio | Palermo FC | 2:1 |
| 23-09-25 20:00 | AC Milão | US Lecce | 3:0 |
| 24-09-25 16:00 | Parma Calcio 1913 | Spezia Calcio | 6:5a.pen./2:290m |
| 24-09-25 17:30 | Hellas Verona | FC Venezia | 4:5a.pen./0:090m |
| 24-09-25 20:00 | Como Calcio | Sassuolo Calcio | 3:0 |
| 25-09-25 17:30 | Genua CFC | FC Empoli | 3:1 |
| 25-09-25 20:00 | FC Torino | Pisa Sporting Club | 1:0 |
| 30-09-25 19:30 | Palermo FC | FC Venezia | 0:0 |
| 30-09-25 19:30 | Juve Stabia | Mantova 1911 | 2:1 |
| 30-09-25 19:30 | Padova Calcio | US Avellino | 2:2 |
| 30-09-25 19:30 | AC Reggiana 1919 | Spezia Calcio | 1:1 |
| 30-09-25 19:30 | Virtus Entella | SSC Bari | 2:2 |
| 30-09-25 19:30 | Frosinone Calcio | FC Cesena | 3:1 |
| 01-10-25 19:30 | Pescara Calcio | FC Südtirol | 1:1 |
| 01-10-25 19:30 | Sampdoria Génova | US Catanzaro 1929 | 0:0 |
| 01-10-25 19:30 | Carrarese Calcio 1908 | Modena FC | 0:0 |
| 01-10-25 19:30 | FC Empoli | AC Monza | 1:1 |
| 03-10-25 19:45 | Hellas Verona | Sassuolo Calcio | 0:1 |
| 04-10-25 14:00 | Lazio Roma | FC Torino | 3:3 |
| 04-10-25 14:00 | Parma Calcio 1913 | US Lecce | 0:1 |
| 04-10-25 17:00 | Inter Milão | US Cremonese | 4:1 |
| 04-10-25 19:45 | Atalanta Bergamo | Como Calcio | 1:1 |
| 05-10-25 11:30 | Udinese Calcio | Cagliari Calcio | 1:1 |
| 05-10-25 14:00 | FC Bologna | Pisa Sporting Club | 4:0 |
| 05-10-25 14:00 | AC Fiorentina | AS Roma | 1:2 |
| 05-10-25 17:00 | SSC Nápoles | Genua CFC | 2:1 |
| 05-10-25 19:45 | Juventus Turim | AC Milão | 0:0 |