| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 29-08-25 17:30 | US Cremonese | Sassuolo Calcio | 3:2 |
| 29-08-25 19:30 | AC Reggiana 1919 | FC Empoli | 3:1 |
| 29-08-25 19:45 | US Lecce | AC Milão | 0:2 |
| 30-08-25 17:30 | Parma Calcio 1913 | Atalanta Bergamo | 1:1 |
| 30-08-25 17:30 | FC Bologna | Como Calcio | 1:0 |
| 30-08-25 18:00 | Juve Stabia | FC Venezia | 0:0 |
| 30-08-25 18:00 | Mantova 1911 | Pescara Calcio | 2:1 |
| 30-08-25 19:45 | SSC Nápoles | Cagliari Calcio | 1:0 |
| 30-08-25 19:45 | Pisa Sporting Club | AS Roma | 0:1 |
| 30-08-25 20:00 | FC Cesena | Virtus Entella | 1:1 |
| 30-08-25 20:00 | Palermo FC | Frosinone Calcio | 0:0 |
| 30-08-25 20:00 | Spezia Calcio | US Catanzaro 1929 | 0:0 |
| 31-08-25 17:30 | Genua CFC | Juventus Turim | 0:1 |
| 31-08-25 17:30 | FC Torino | AC Fiorentina | 0:0 |
| 31-08-25 18:00 | Carrarese Calcio 1908 | Padova Calcio | 0:0 |
| 31-08-25 18:00 | FC Südtirol | Sampdoria Génova | 3:1 |
| 31-08-25 19:45 | Lazio Roma | Hellas Verona | 4:0 |
| 31-08-25 19:45 | Inter Milão | Udinese Calcio | 1:2 |
| 31-08-25 20:00 | SSC Bari | AC Monza | 1:1 |
| 31-08-25 20:00 | Modena FC | US Avellino | 1:1 |