| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 13-08-21 19:30 | 13-08-21 19:30 | Bor. Mönchengladbach | FC Bayern Munique | 1:1 | 3 - 5 pontos |
| 14-08-21 14:30 | 14-08-21 14:30 | VfL Wolfsburgo | VfL Bochum | 1:0 | 3 - 5 pontos |
| 14-08-21 14:30 | 14-08-21 14:30 | 1. FC Union Berlim | Bayer 04 Leverkusen | 1:1 | 3 - 5 pontos |
| 14-08-21 14:30 | 14-08-21 14:30 | VfB Estugarda | SpVgg Greuther Fürth | 5:1 | 3 - 5 pontos |
| 14-08-21 14:30 | 14-08-21 14:30 | FC Augsburg | 1899 Hoffenheim | 0:4 | 3 - 5 pontos |
| 14-08-21 14:30 | 14-08-21 14:30 | Arminia Bielefeld | SC Friburgo | 0:0 | 3 - 5 pontos |
| 14-08-21 17:30 | 14-08-21 17:30 | Borussia Dortmund | Eintracht Frankfurt | 5:2 | 3 - 5 pontos |
| 15-08-21 14:30 | 15-08-21 14:30 | FSV Mainz 05 | RB Leipzig | 1:0 | 3 - 5 pontos |
| 15-08-21 16:30 | 15-08-21 16:30 | 1. FC Colónia | Hertha BSC Berlim | 3:1 | 3 - 5 pontos |