Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 10-03-22 17:45 | 10-03-22 17:45 | PAOK Salónica | KAA Gent | 1:0 | 2 - 4 pontos |
| 10-03-22 17:45 | 10-03-22 17:45 | Slavia Praga | Linzer ASK | 4:1 | 2 - 4 pontos |
| 10-03-22 17:45 | 10-03-22 17:45 | Vitesse Arnheim | AS Roma | 0:1 | 2 - 4 pontos |
| 10-03-22 17:45 | 10-03-22 17:45 | Partizan Belgrado | Feyenoord Rotterdão | 2:5 | 2 - 4 pontos |
| 10-03-22 20:00 | 10-03-22 20:00 | Olympique Marselha | FC Basileia | 2:1 | 2 - 4 pontos |
| 10-03-22 20:00 | 10-03-22 20:00 | Leicester City | Stade Rennes | 2:0 | 2 - 4 pontos |
| 10-03-22 20:00 | 10-03-22 20:00 | PSV Eindhoven | FC Copenhaga | 4:4 | 2 - 4 pontos |
| 10-03-22 20:00 | 10-03-22 20:00 | FK Bodö/Glimt | AZ Alkmaar | 2:1 | 2 - 4 pontos |