Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Grupo | Resultado | Regra de pontuação |
|---|---|---|---|---|---|---|
| 03-11-22 15:30 | 03-11-22 15:30 | Rigas Futbola Skola | AC Fiorentina | Grupo A | 0:3 | 2 - 4 pontos |
| 03-11-22 15:30 | 03-11-22 15:30 | Istambul Basaksehir FK | Heart of Midlothian | Grupo A | 3:1 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | Zalgiris Vilnius | SK Slovan Bratislava | Grupo H | 1:2 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | Slavia Praga | Sivasspor | Grupo G | 1:1 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | Pyunik | FC Basileia | Grupo H | 1:2 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | Djurgardens IF | Shamrock Rovers | Grupo F | 1:0 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | CFR Cluj | KF Ballkani Suhareka | Grupo G | 1:0 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | KAA Gent | Molde FK | Grupo F | 4:0 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | AZ Alkmaar | SK Dnipro-1 | Grupo E | 2:1 | 2 - 4 pontos |
| 03-11-22 17:45 | 03-11-22 17:45 | Apollon Limassol FC | FC Vaduz | Grupo E | 1:0 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | 1. FC Colónia | OGC Nice | Grupo D | 2:2 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | Partizan Belgrado | 1. FC Slovacko | Grupo D | 1:1 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | Lech Poznan | FC Villarreal | Grupo C | 3:0 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | Hapoel Beer Sheva | FK Austria Vienna | Grupo C | 4:0 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | FCSB Bukarest | West Ham United | Grupo B | 0:3 | 2 - 4 pontos |
| 03-11-22 20:00 | 03-11-22 20:00 | Silkeborg IF | RSC Anderlecht | Grupo B | 0:2 | 2 - 4 pontos |