Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17-03-22 17:45 | 17-03-22 17:45 | AZ Alkmaar | FK Bodö/Glimt | 2:2a.p. | 2 - 4 pontos |
| 17-03-22 17:45 | 17-03-22 17:45 | FC Basileia | Olympique Marselha | 1:2 | 2 - 4 pontos |
| 17-03-22 17:45 | 17-03-22 17:45 | Stade Rennes | Leicester City | 2:1 | 2 - 4 pontos |
| 17-03-22 17:45 | 17-03-22 17:45 | FC Copenhaga | PSV Eindhoven | 0:4 | 2 - 4 pontos |
| 17-03-22 20:00 | 17-03-22 20:00 | Linzer ASK | Slavia Praga | 4:3 | 2 - 4 pontos |
| 17-03-22 20:00 | 17-03-22 20:00 | AS Roma | Vitesse Arnheim | 1:1 | 2 - 4 pontos |
| 17-03-22 20:00 | 17-03-22 20:00 | KAA Gent | PAOK Salónica | 1:2 | 2 - 4 pontos |
| 17-03-22 20:00 | 17-03-22 20:00 | Feyenoord Rotterdão | Partizan Belgrado | 3:1 | 2 - 4 pontos |