Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25-02-22 19:30 | 25-02-22 19:30 | 1899 Hoffenheim | VfB Estugarda | 2:1 | 2 - 10 - 8 |
| 26-02-22 14:30 | 26-02-22 14:30 | SC Friburgo | Hertha BSC Berlim | 3:0 | 2 - 10 - 10 |
| 26-02-22 14:30 | 26-02-22 14:30 | Bor. Mönchengladbach | VfL Wolfsburgo | 2:2 | 5 - 4 - 3 |
| 26-02-22 14:30 | 26-02-22 14:30 | 1. FC Union Berlim | FSV Mainz 05 | 3:1 | 4 - 4 - 4 |
| 26-02-22 14:30 | 26-02-22 14:30 | Bayer 04 Leverkusen | Arminia Bielefeld | 3:0 | 2 - 10 - 10 |
| 26-02-22 14:30 | 26-02-22 14:30 | SpVgg Greuther Fürth | 1. FC Colónia | 1:1 | 10 - 6 - 2 |
| 26-02-22 17:30 | 26-02-22 17:30 | Eintracht Frankfurt | FC Bayern Munique | 0:1 | 7 - 7 - 2 |
| 27-02-22 14:30 | 27-02-22 14:30 | VfL Bochum | RB Leipzig | 0:1 | 6 - 7 - 3 |
| 27-02-22 16:30 | 27-02-22 16:30 | FC Augsburg | Borussia Dortmund | 1:1 | 9 - 10 - 2 |