Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 11-02-22 19:30 | 11-02-22 19:30 | RB Leipzig | 1. FC Colónia | 3:1 | 3 - 8 - 5 |
| 12-02-22 14:30 | 12-02-22 14:30 | Bor. Mönchengladbach | FC Augsburg | 3:2 | 3 - 5 - 4 |
| 12-02-22 14:30 | 12-02-22 14:30 | Eintracht Frankfurt | VfL Wolfsburgo | 0:2 | 2 - 7 - 9 |
| 12-02-22 14:30 | 12-02-22 14:30 | SpVgg Greuther Fürth | Hertha BSC Berlim | 2:1 | 6 - 5 - 3 |
| 12-02-22 14:30 | 12-02-22 14:30 | VfL Bochum | FC Bayern Munique | 4:2 | 10 - 10 - 2 |
| 12-02-22 14:30 | 12-02-22 14:30 | SC Friburgo | FSV Mainz 05 | 1:1 | 3 - 7 - 6 |
| 12-02-22 17:30 | 12-02-22 17:30 | Bayer 04 Leverkusen | VfB Estugarda | 4:2 | 2 - 10 - 10 |
| 13-02-22 14:30 | 13-02-22 14:30 | 1. FC Union Berlim | Borussia Dortmund | 0:3 | 6 - 6 - 3 |
| 13-02-22 16:30 | 13-02-22 16:30 | 1899 Hoffenheim | Arminia Bielefeld | 2:0 | 3 - 5 - 8 |