| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 22-09-21 18:00 | FC Nantes | Stade Brest 29 | 3:1 |
| 22-09-21 18:00 | Stade Rennes | Clermont Foot | 6:0 |
| 22-09-21 18:00 | OSC Lille | Stade Reims | 2:1 |
| 22-09-21 18:00 | AS Mónaco | AS St. Etienne | 3:1 |
| 22-09-21 18:00 | HSC Montpellier | Girondins Bordeaux | 3:3 |
| 22-09-21 20:00 | SCO Angers | Olympique Marselha | 0:0 |
| 22-09-21 20:00 | RC Lens | Racing Club Estrasburgo | 0:1 |
| 22-09-21 20:00 | FC Lorient | OGC Nice | 1:0 |
| 22-09-21 20:00 | Olympique Lyon | ES Troyes AC | 3:1 |
| 22-09-21 20:00 | FC Metz | Paris St. Germain | 1:2 |