Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 06-05-22 17:30 | 06-05-22 17:30 | Fortuna Düsseldorf | SV Darmstadt 98 | 2:1 | 2 - 4 pontos |
| 06-05-22 17:30 | 06-05-22 17:30 | SC Paderborn 07 | SV Sandhausen | 2:0 | 2 - 4 pontos |
| 07-05-22 12:30 | 07-05-22 12:30 | Hamburgo SV | Hannover 96 | 2:1 | 2 - 4 pontos |
| 07-05-22 12:30 | 07-05-22 12:30 | Jahn Regensburg | 1. FC Heidenheim 1846 | 0:2 | 2 - 4 pontos |
| 07-05-22 12:30 | 07-05-22 12:30 | FC Ingolstadt | FC Hansa Rostock | 0:0 | 2 - 4 pontos |
| 07-05-22 19:30 | 07-05-22 19:30 | FC Schalke 04 | FC St. Pauli | 3:2 | 2 - 4 pontos |
| 08-05-22 12:30 | 08-05-22 12:30 | Holstein Kiel | 1. FC Nuremberga | 3:0 | 2 - 4 pontos |
| 08-05-22 12:30 | 08-05-22 12:30 | Karlsruher SC | Dynamo Dresden | 2:2 | 2 - 4 pontos |
| 08-05-22 12:30 | 08-05-22 12:30 | Erzgebirge Aue | Werder Bremen | 0:3 | 2 - 4 pontos |