Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 18-03-22 17:30 | 18-03-22 17:30 | FC St. Pauli | 1. FC Heidenheim 1846 | 1:0 | 2 - 4 pontos |
| 18-03-22 17:30 | 18-03-22 17:30 | Erzgebirge Aue | Karlsruher SC | 0:3 | 2 - 4 pontos |
| 19-03-22 12:30 | 19-03-22 12:30 | FC Schalke 04 | Hannover 96 | 2:1 | 2 - 4 pontos |
| 19-03-22 12:30 | 19-03-22 12:30 | Fortuna Düsseldorf | Hamburgo SV | 1:1 | 2 - 4 pontos |
| 19-03-22 12:30 | 19-03-22 12:30 | SV Sandhausen | FC Hansa Rostock | 0:1 | 2 - 4 pontos |
| 19-03-22 19:30 | 19-03-22 19:30 | Werder Bremen | SV Darmstadt 98 | 1:0 | 2 - 4 pontos |
| 20-03-22 12:30 | 20-03-22 12:30 | Holstein Kiel | FC Ingolstadt | 1:0 | 2 - 4 pontos |
| 20-03-22 12:30 | 20-03-22 12:30 | 1. FC Nuremberga | Dynamo Dresden | 1:1 | 2 - 4 pontos |
| 20-03-22 12:30 | 20-03-22 12:30 | Jahn Regensburg | SC Paderborn 07 | 1:0 | 2 - 4 pontos |