| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 09-03-22 17:45 | FC Porto | Olympique Lyon | 0:1 |
| 09-03-22 17:45 | Real Betis Sevilla | Eintracht Frankfurt | 1:2 |
| 10-03-22 17:45 | FC Sevilla | West Ham United | 1:0 |
| 10-03-22 20:00 | FC Barcelona | Galatasaray Istambul | 0:0 |
| 10-03-22 20:00 | Sporting Braga | AS Mónaco | 2:0 |
| 10-03-22 20:00 | Glasgow Rangers | Estrela Vermelha Belgrado | 3:0 |
| 10-03-22 20:00 | Atalanta Bergamo | Bayer 04 Leverkusen | 3:2 |