| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 23-10-25 17:45 | KRC Genk | Real Betis Sevilla | 0:0 |
| 23-10-25 17:45 | FC Red Bull Salzburgo | Ferencvaros Budapest | 2:3 |
| 23-10-25 17:45 | Brann Bergen | Glasgow Rangers | 3:0 |
| 23-10-25 17:45 | Sporting Braga | Estrela Vermelha Belgrado | 2:0 |
| 23-10-25 17:45 | Olympique Lyon | FC Basileia | 2:0 |
| 23-10-25 17:45 | Go Ahead Eagles Deventer | Aston Villa | 2:1 |
| 23-10-25 17:45 | FCSB Bukarest | FC Bologna | 1:2 |
| 23-10-25 17:45 | Fenerbahce Istambul | VfB Estugarda | 1:0 |
| 23-10-25 20:00 | Feyenoord Rotterdão | Panathinaikos Atenas | 3:1 |
| 23-10-25 20:00 | Maccabi Tel Avive | FC Midtjylland | 0:3 |
| 23-10-25 20:00 | OSC Lille | PAOK Salónica | 3:4 |
| 23-10-25 20:00 | Celtic Glasgow | SK Sturm Graz | 2:1 |
| 23-10-25 20:00 | Malmö FF | Dínamo Zagreb | 1:1 |
| 23-10-25 20:00 | SC Friburgo | FC Utrecht | 2:0 |
| 23-10-25 20:00 | Nottingham Forest | FC Porto | 2:0 |
| 23-10-25 20:00 | Young Boys Berna | PFC Ludogorets Razgrad | 3:2 |
| 23-10-25 20:00 | AS Roma | Viktoria Plzeň | 1:2 |
| 23-10-25 20:00 | Celta Vigo | OGC Nice | 2:1 |