| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 25-11-25 17:45 | Ajax Amsterdão | Benfica | 0:2 |
| 25-11-25 17:45 | Galatasaray Istambul | Royale Union Saint-Gilloise | 0:1 |
| 25-11-25 20:00 | FK Bodö/Glimt | Juventus Turim | 2:3 |
| 25-11-25 20:00 | Borussia Dortmund | FC Villarreal | 4:0 |
| 25-11-25 20:00 | SSC Nápoles | Qarabag | 2:0 |
| 25-11-25 20:00 | Slavia Praga | Athletic Bilbao | 0:0 |
| 25-11-25 20:00 | Manchester City | Bayer 04 Leverkusen | 0:2 |
| 25-11-25 20:00 | Olympique Marselha | Newcastle United | 2:1 |
| 25-11-25 20:00 | FC Chelsea | FC Barcelona | 3:0 |
| 26-11-25 17:45 | Pafos FC | AS Mónaco | 2:2 |
| 26-11-25 17:45 | FC Copenhaga | Kairat Almaty | 3:2 |
| 26-11-25 20:00 | FC Arsenal | FC Bayern Munique | 3:1 |
| 26-11-25 20:00 | FC Liverpool | PSV Eindhoven | 1:4 |
| 26-11-25 20:00 | Sporting | FC Brugges | 3:0 |
| 26-11-25 20:00 | Eintracht Frankfurt | Atalanta Bergamo | 0:3 |
| 26-11-25 20:00 | Paris St. Germain | Tottenham Hotspurs | 5:3 |
| 26-11-25 20:00 | Atlético Madrid | Inter Milão | 2:1 |
| 26-11-25 20:00 | Olympiakos Pireu | Real Madrid | 3:4 |