| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-10-25 17:45 | FC Barcelona | Olympiakos Pireu | 6:1 |
| 21-10-25 17:45 | Kairat Almaty | Pafos FC | 0:0 |
| 21-10-25 20:00 | PSV Eindhoven | SSC Nápoles | 6:2 |
| 21-10-25 20:00 | FC Villarreal | Manchester City | 0:2 |
| 21-10-25 20:00 | FC Copenhaga | Borussia Dortmund | 2:4 |
| 21-10-25 20:00 | Royale Union Saint-Gilloise | Inter Milão | 0:4 |
| 21-10-25 20:00 | FC Arsenal | Atlético Madrid | 4:0 |
| 21-10-25 20:00 | Newcastle United | Benfica | 3:0 |
| 21-10-25 20:00 | Bayer 04 Leverkusen | Paris St. Germain | 2:7 |
| 22-10-25 17:45 | Galatasaray Istambul | FK Bodö/Glimt | 3:1 |
| 22-10-25 17:45 | Athletic Bilbao | Qarabag | 3:1 |
| 22-10-25 20:00 | Real Madrid | Juventus Turim | 1:0 |
| 22-10-25 20:00 | FC Bayern Munique | FC Brugges | 4:0 |
| 22-10-25 20:00 | FC Chelsea | Ajax Amsterdão | 5:1 |
| 22-10-25 20:00 | Eintracht Frankfurt | FC Liverpool | 1:5 |
| 22-10-25 20:00 | Atalanta Bergamo | Slavia Praga | 0:0 |
| 22-10-25 20:00 | Sporting | Olympique Marselha | 2:1 |
| 22-10-25 20:00 | AS Mónaco | Tottenham Hotspurs | 0:0 |