| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 16-09-25 17:45 | Athletic Bilbao | FC Arsenal | 0:2 |
| 16-09-25 17:45 | PSV Eindhoven | Royale Union Saint-Gilloise | 1:3 |
| 16-09-25 20:00 | Tottenham Hotspurs | FC Villarreal | 1:0 |
| 16-09-25 20:00 | Benfica | Qarabag | 2:3 |
| 16-09-25 20:00 | Juventus Turim | Borussia Dortmund | 4:4 |
| 16-09-25 20:00 | Real Madrid | Olympique Marselha | 2:1 |
| 17-09-25 17:45 | Olympiakos Pireu | Pafos FC | 0:0 |
| 17-09-25 17:45 | Slavia Praga | FK Bodö/Glimt | 2:2 |
| 17-09-25 20:00 | Paris St. Germain | Atalanta Bergamo | 4:0 |
| 17-09-25 20:00 | FC Liverpool | Atlético Madrid | 3:2 |
| 17-09-25 20:00 | Ajax Amsterdão | Inter Milão | 0:2 |
| 17-09-25 20:00 | FC Bayern Munique | FC Chelsea | 3:1 |
| 18-09-25 17:45 | FC Brugges | AS Mónaco | 4:1 |
| 18-09-25 17:45 | FC Copenhaga | Bayer 04 Leverkusen | 2:2 |
| 18-09-25 20:00 | Sporting | Kairat Almaty | 4:1 |
| 18-09-25 20:00 | Eintracht Frankfurt | Galatasaray Istambul | 5:1 |
| 18-09-25 20:00 | Manchester City | SSC Nápoles | 2:0 |
| 18-09-25 20:00 | Newcastle United | FC Barcelona | 1:2 |