| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 22-01-26 17:45 | Viktoria Plzeň | FC Porto | 1:1 |
| 22-01-26 17:45 | Young Boys Berna | Olympique Lyon | 0:1 |
| 22-01-26 17:45 | Feyenoord Rotterdão | SK Sturm Graz | 3:0 |
| 22-01-26 17:45 | SC Friburgo | Maccabi Tel Avive | 1:0 |
| 22-01-26 17:45 | PAOK Salónica | Real Betis Sevilla | 2:0 |
| 22-01-26 17:45 | FC Bologna | Celtic Glasgow | 2:2 |
| 22-01-26 17:45 | Malmö FF | Estrela Vermelha Belgrado | 0:1 |
| 22-01-26 17:45 | Fenerbahce Istambul | Aston Villa | 0:1 |
| 22-01-26 17:45 | Brann Bergen | FC Midtjylland | 3:3 |
| 22-01-26 20:00 | Ferencvaros Budapest | Panathinaikos Atenas | 1:1 |
| 22-01-26 20:00 | OGC Nice | Go Ahead Eagles Deventer | 3:1 |
| 22-01-26 20:00 | Celta Vigo | OSC Lille | 2:1 |
| 22-01-26 20:00 | Sporting Braga | Nottingham Forest | 1:0 |
| 22-01-26 20:00 | FC Red Bull Salzburgo | FC Basileia | 3:1 |
| 22-01-26 20:00 | Dínamo Zagreb | FCSB Bukarest | 4:1 |
| 22-01-26 20:00 | Glasgow Rangers | PFC Ludogorets Razgrad | 1:0 |
| 22-01-26 20:00 | AS Roma | VfB Estugarda | 2:0 |
| 22-01-26 20:50 | FC Utrecht | KRC Genk | 0:2 |