| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 27-11-25 17:45 | PAOK Salónica | Brann Bergen | 1:1 |
| 27-11-25 17:45 | PFC Ludogorets Razgrad | Celta Vigo | 3:2 |
| 27-11-25 17:45 | Feyenoord Rotterdão | Celtic Glasgow | 1:3 |
| 27-11-25 17:45 | OSC Lille | Dínamo Zagreb | 4:0 |
| 27-11-25 17:45 | Aston Villa | Young Boys Berna | 2:1 |
| 27-11-25 17:45 | FC Porto | OGC Nice | 3:0 |
| 27-11-25 17:45 | Fenerbahce Istambul | Ferencvaros Budapest | 1:1 |
| 27-11-25 17:45 | Viktoria Plzeň | SC Friburgo | 0:0 |
| 27-11-25 17:45 | AS Roma | FC Midtjylland | 2:1 |
| 27-11-25 20:00 | KRC Genk | FC Basileia | 2:1 |
| 27-11-25 20:00 | Nottingham Forest | Malmö FF | 3:0 |
| 27-11-25 20:00 | Go Ahead Eagles Deventer | VfB Estugarda | 0:4 |
| 27-11-25 20:00 | Panathinaikos Atenas | SK Sturm Graz | 2:1 |
| 27-11-25 20:00 | FC Bologna | FC Red Bull Salzburgo | 4:1 |
| 27-11-25 20:00 | Maccabi Tel Avive | Olympique Lyon | 0:6 |
| 27-11-25 20:00 | Estrela Vermelha Belgrado | FCSB Bukarest | 1:0 |
| 27-11-25 20:00 | Glasgow Rangers | Sporting Braga | 1:1 |
| 27-11-25 20:00 | Real Betis Sevilla | FC Utrecht | 2:1 |