| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 06-11-25 17:45 | FC Utrecht | FC Porto | 1:1 |
| 06-11-25 17:45 | FC Red Bull Salzburgo | Go Ahead Eagles Deventer | 2:0 |
| 06-11-25 17:45 | Estrela Vermelha Belgrado | OSC Lille | 1:0 |
| 06-11-25 17:45 | SK Sturm Graz | Nottingham Forest | 0:0 |
| 06-11-25 17:45 | FC Midtjylland | Celtic Glasgow | 3:1 |
| 06-11-25 17:45 | FC Basileia | FCSB Bukarest | 3:1 |
| 06-11-25 17:45 | Dínamo Zagreb | Celta Vigo | 0:3 |
| 06-11-25 17:45 | Malmö FF | Panathinaikos Atenas | 0:1 |
| 06-11-25 17:45 | OGC Nice | SC Friburgo | 1:3 |
| 06-11-25 20:00 | FC Bologna | Brann Bergen | 0:0 |
| 06-11-25 20:00 | Sporting Braga | KRC Genk | 3:4 |
| 06-11-25 20:00 | PAOK Salónica | Young Boys Berna | 4:0 |
| 06-11-25 20:00 | Aston Villa | Maccabi Tel Avive | 2:0 |
| 06-11-25 20:00 | VfB Estugarda | Feyenoord Rotterdão | 2:0 |
| 06-11-25 20:00 | Ferencvaros Budapest | PFC Ludogorets Razgrad | 3:1 |
| 06-11-25 20:00 | Glasgow Rangers | AS Roma | 0:2 |
| 06-11-25 20:00 | Real Betis Sevilla | Olympique Lyon | 2:0 |
| 06-11-25 20:00 | Viktoria Plzeň | Fenerbahce Istambul | 0:0 |