| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-10-25 17:45 | FC Bologna | SC Friburgo | 1:1 |
| 02-10-25 17:45 | FCSB Bukarest | Young Boys Berna | 0:2 |
| 02-10-25 17:45 | Viktoria Plzeň | Malmö FF | 3:0 |
| 02-10-25 17:45 | Celtic Glasgow | Sporting Braga | 0:2 |
| 02-10-25 17:45 | Panathinaikos Atenas | Go Ahead Eagles Deventer | 1:2 |
| 02-10-25 17:45 | Fenerbahce Istambul | OGC Nice | 2:1 |
| 02-10-25 17:45 | AS Roma | OSC Lille | 0:1 |
| 02-10-25 17:45 | Brann Bergen | FC Utrecht | 1:0 |
| 02-10-25 17:45 | PFC Ludogorets Razgrad | Real Betis Sevilla | 0:2 |
| 02-10-25 20:00 | Feyenoord Rotterdão | Aston Villa | 0:2 |
| 02-10-25 20:00 | FC Porto | Estrela Vermelha Belgrado | 2:1 |
| 02-10-25 20:00 | FC Basileia | VfB Estugarda | 2:0 |
| 02-10-25 20:00 | Olympique Lyon | FC Red Bull Salzburgo | 2:0 |
| 02-10-25 20:00 | KRC Genk | Ferencvaros Budapest | 0:1 |
| 02-10-25 20:00 | Maccabi Tel Avive | Dínamo Zagreb | 1:3 |
| 02-10-25 20:00 | Nottingham Forest | FC Midtjylland | 2:3 |
| 02-10-25 20:00 | SK Sturm Graz | Glasgow Rangers | 2:1 |
| 02-10-25 20:00 | Celta Vigo | PAOK Salónica | 3:1 |