| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 24-09-25 17:45 | PAOK Salónica | Maccabi Tel Avive | 0:0 |
| 24-09-25 17:45 | FC Midtjylland | SK Sturm Graz | 2:0 |
| 24-09-25 20:00 | Dínamo Zagreb | Fenerbahce Istambul | 3:1 |
| 24-09-25 20:00 | Estrela Vermelha Belgrado | Celtic Glasgow | 1:1 |
| 24-09-25 20:00 | Sporting Braga | Feyenoord Rotterdão | 1:0 |
| 24-09-25 20:00 | Real Betis Sevilla | Nottingham Forest | 2:2 |
| 24-09-25 20:00 | Malmö FF | PFC Ludogorets Razgrad | 1:2 |
| 24-09-25 20:00 | SC Friburgo | FC Basileia | 2:1 |
| 24-09-25 20:00 | OGC Nice | AS Roma | 1:2 |
| 25-09-25 17:45 | OSC Lille | Brann Bergen | 2:1 |
| 25-09-25 17:45 | Go Ahead Eagles Deventer | FCSB Bukarest | 0:1 |
| 25-09-25 20:00 | Glasgow Rangers | KRC Genk | 0:1 |
| 25-09-25 20:00 | Ferencvaros Budapest | Viktoria Plzeň | 1:1 |
| 25-09-25 20:00 | Young Boys Berna | Panathinaikos Atenas | 1:4 |
| 25-09-25 20:00 | Aston Villa | FC Bologna | 1:0 |
| 25-09-25 20:00 | FC Red Bull Salzburgo | FC Porto | 0:1 |
| 25-09-25 20:00 | FC Utrecht | Olympique Lyon | 0:1 |
| 25-09-25 20:00 | VfB Estugarda | Celta Vigo | 2:1 |