| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-12-25 20:00 | FC Lausanne-Sport | AC Fiorentina | 1:0 |
| 18-12-25 20:00 | AZ Alkmaar | Jagiellonia Bialystok | 0:0 |
| 18-12-25 20:00 | Shaktiar Donetsk | HNK Rijeka | 0:0 |
| 18-12-25 20:00 | SK Slovan Bratislava | BK Häcken | 1:0 |
| 18-12-25 20:00 | Legia Varsóvia | Lincoln Red Imps FC | 4:1 |
| 18-12-25 20:00 | Sparta Praga | FC Aberdeen | 3:0 |
| 18-12-25 20:00 | Dínamo Kiev | FC Noah | 2:0 |
| 18-12-25 20:00 | Crystal Palace | Kuopion PS | 2:2 |
| 18-12-25 20:00 | Rayo Vallecano | KF Drita Gjilan | 3:0 |
| 18-12-25 20:00 | Shamrock Rovers | Hamrun Spartans | 3:1 |
| 18-12-25 20:00 | Omonia Nicosia | KS Rakow Czestochowa | 0:1 |
| 18-12-25 20:00 | FSV Mainz 05 | Samsunspor | 2:0 |
| 18-12-25 20:00 | Racing Club Estrasburgo | Breidablik Kopavogur | 3:1 |
| 18-12-25 20:00 | NK Celje | FC Shelbourne | 0:0 |
| 18-12-25 20:00 | HŠK Zrinjski Mostar | SK Rapid Vienna | 1:1 |
| 18-12-25 20:00 | AEK Atenas | Universitatea Craiova | 3:2 |
| 18-12-25 20:00 | Sigma Olomouc | Lech Poznan | 1:2 |
| 18-12-25 20:00 | AEK Larnaca | KF Shkendija | 1:0 |