| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 27-11-25 17:45 | AZ Alkmaar | FC Shelbourne | 2:0 |
| 27-11-25 17:45 | SK Slovan Bratislava | Rayo Vallecano | 2:1 |
| 27-11-25 17:45 | Lech Poznan | FC Lausanne-Sport | 2:0 |
| 27-11-25 17:45 | Omonia Nicosia | Dínamo Kiev | 2:0 |
| 27-11-25 17:45 | HŠK Zrinjski Mostar | BK Häcken | 2:1 |
| 27-11-25 17:45 | Sigma Olomouc | NK Celje | 2:1 |
| 27-11-25 17:45 | KS Rakow Czestochowa | SK Rapid Vienna | 4:1 |
| 27-11-25 17:45 | Universitatea Craiova | FSV Mainz 05 | 1:0 |
| 27-11-25 17:45 | Hamrun Spartans | Lincoln Red Imps FC | 3:1 |
| 27-11-25 20:00 | Legia Varsóvia | Sparta Praga | 0:1 |
| 27-11-25 20:00 | Shamrock Rovers | Shaktiar Donetsk | 1:2 |
| 27-11-25 20:00 | Racing Club Estrasburgo | Crystal Palace | 2:1 |
| 27-11-25 20:00 | Jagiellonia Bialystok | Kuopion PS | 1:0 |
| 27-11-25 20:00 | HNK Rijeka | AEK Larnaca | 0:0 |
| 27-11-25 20:00 | FC Aberdeen | FC Noah | 1:1 |
| 27-11-25 20:00 | KF Drita Gjilan | KF Shkendija | 1:0 |
| 27-11-25 20:00 | Breidablik Kopavogur | Samsunspor | 2:2 |
| 27-11-25 20:00 | AC Fiorentina | AEK Atenas | 0:1 |