| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 06-11-25 17:45 | Samsunspor | Hamrun Spartans | 3:0 |
| 06-11-25 17:45 | Shaktiar Donetsk | Breidablik Kopavogur | 2:0 |
| 06-11-25 17:45 | Sparta Praga | KS Rakow Czestochowa | 0:0 |
| 06-11-25 17:45 | NK Celje | Legia Varsóvia | 2:1 |
| 06-11-25 17:45 | Kuopion PS | SK Slovan Bratislava | 3:1 |
| 06-11-25 17:45 | AEK Atenas | Shamrock Rovers | 1:1 |
| 06-11-25 17:45 | AEK Larnaca | FC Aberdeen | 0:0 |
| 06-11-25 17:45 | FC Noah | Sigma Olomouc | 1:2 |
| 06-11-25 17:45 | FSV Mainz 05 | AC Fiorentina | 2:1 |
| 06-11-25 20:00 | SK Rapid Vienna | Universitatea Craiova | 0:1 |
| 06-11-25 20:00 | Dínamo Kiev | HŠK Zrinjski Mostar | 6:0 |
| 06-11-25 20:00 | Crystal Palace | AZ Alkmaar | 3:1 |
| 06-11-25 20:00 | Rayo Vallecano | Lech Poznan | 3:2 |
| 06-11-25 20:00 | Lincoln Red Imps FC | HNK Rijeka | 1:1 |
| 06-11-25 20:00 | KF Shkendija | Jagiellonia Bialystok | 1:1 |
| 06-11-25 20:00 | BK Häcken | Racing Club Estrasburgo | 1:2 |
| 06-11-25 20:00 | FC Lausanne-Sport | Omonia Nicosia | 1:1 |
| 06-11-25 20:00 | FC Shelbourne | KF Drita Gjilan | 0:1 |