| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-10-25 17:45 | Rayo Vallecano | KF Shkendija | 2:0 |
| 02-10-25 17:45 | Jagiellonia Bialystok | Hamrun Spartans | 1:0 |
| 02-10-25 17:45 | Lech Poznan | SK Rapid Vienna | 4:1 |
| 02-10-25 17:45 | Omonia Nicosia | FSV Mainz 05 | 0:1 |
| 02-10-25 17:45 | FC Noah | HNK Rijeka | 1:0 |
| 02-10-25 17:45 | FC Lausanne-Sport | Breidablik Kopavogur | 3:0 |
| 02-10-25 17:45 | HŠK Zrinjski Mostar | Lincoln Red Imps FC | 5:0 |
| 02-10-25 17:45 | Kuopion PS | KF Drita Gjilan | 1:1 |
| 02-10-25 17:45 | Dínamo Kiev | Crystal Palace | 0:2 |
| 02-10-25 20:00 | NK Celje | AEK Atenas | 3:1 |
| 02-10-25 20:00 | FC Shelbourne | BK Häcken | 0:0 |
| 02-10-25 20:00 | AEK Larnaca | AZ Alkmaar | 4:0 |
| 02-10-25 20:00 | FC Aberdeen | Shaktiar Donetsk | 2:3 |
| 02-10-25 20:00 | KS Rakow Czestochowa | Universitatea Craiova | 2:0 |
| 02-10-25 20:00 | Sparta Praga | Shamrock Rovers | 4:1 |
| 02-10-25 20:00 | SK Slovan Bratislava | Racing Club Estrasburgo | 1:2 |
| 02-10-25 20:00 | Legia Varsóvia | Samsunspor | 0:1 |
| 02-10-25 20:00 | AC Fiorentina | Sigma Olomouc | 2:0 |