Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 14-12-21 17:30 | 14-12-21 17:30 | VfB Estugarda | FC Bayern Munique | 0:5 | 8 - 8 - 2 |
| 14-12-21 19:30 | 14-12-21 19:30 | Arminia Bielefeld | VfL Bochum | 2:0 | 4 - 4 - 3 |
| 14-12-21 19:30 | 14-12-21 19:30 | FSV Mainz 05 | Hertha BSC Berlim | 4:0 | 2 - 5 - 7 |
| 14-12-21 19:30 | 14-12-21 19:30 | VfL Wolfsburgo | 1. FC Colónia | 2:3 | 3 - 3 - 6 |
| 15-12-21 17:30 | 15-12-21 17:30 | Bor. Mönchengladbach | Eintracht Frankfurt | 2:3 | 3 - 5 - 3 |
| 15-12-21 19:30 | 15-12-21 19:30 | FC Augsburg | RB Leipzig | 1:1 | 8 - 8 - 2 |
| 15-12-21 19:30 | 15-12-21 19:30 | 1. FC Union Berlim | SC Friburgo | 0:0 | 4 - 4 - 4 |
| 15-12-21 19:30 | 15-12-21 19:30 | Bayer 04 Leverkusen | 1899 Hoffenheim | 2:2 | 2 - 5 - 7 |
| 15-12-21 19:30 | 15-12-21 19:30 | Borussia Dortmund | SpVgg Greuther Fürth | 3:0 | 2 - 8 - 8 |