Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25-11-25 17:45 | 25-11-25 17:45 | Ferencváros | Benfica | 33:31 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | HC Kriens-Luzern | Elverum Håndball | 34:38 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | IK Sävehof | Presov | 33:28 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | Minaur Baia Mare | Slovan | 28:22 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | MT Melsungen | Karlskrona | 35:34 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | Partizan | RK Našice | 30:27 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | Skanderborg AGF | BM Granollers | 28:29 | 2 - 17 pontos |
| 25-11-25 17:45 | 25-11-25 17:45 | St. Raphael | SG Flensburg-Handewitt | 29:36 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | Ademar León | Kadetten Schaffhausen | 30:27 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | CD Bidasoa Irún | Potaissa Turda | 35:30 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | IFK Kristianstad | Toulouse | 34:26 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | Montpellier Handball | BSV Bern Muri | 37:29 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | Ostrow Wielkopolski | THW Kiel | 25:33 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | Porto | Fram | 44:30 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | Sesvete | Vardar 1961 | 24:38 | 2 - 17 pontos |
| 25-11-25 19:45 | 25-11-25 19:45 | TSV Hanôver-Burgdorf | Fredericia HK | 31:34 | 2 - 17 pontos |