Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 14-10-25 17:45 | 14-10-25 17:45 | Ferencváros | Karlskrona | 31:29 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Fredericia HK | TSV Hanôver-Burgdorf | 29:31 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Kadetten Schaffhausen | Ademar León | 30:22 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Montpellier Handball | THW Kiel | 28:30 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | MT Melsungen | Benfica | 28:26 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Potaissa Turda | CD Bidasoa Irún | 33:34 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Presov | IK Sävehof | 30:30 | 2 - 17 pontos |
| 14-10-25 17:45 | 14-10-25 17:45 | Vardar 1961 | Sesvete | 34:29 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | RK Našice | Partizan | 30:22 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | BM Granollers | Skanderborg AGF | 26:31 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | Elverum Håndball | HC Kriens-Luzern | 31:34 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | Fram | Porto | 26:38 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | Ostrow Wielkopolski | BSV Bern Muri | 32:28 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | SG Flensburg-Handewitt | St. Raphael | 32:30 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | Slovan | Minaur Baia Mare | 35:29 | 2 - 17 pontos |
| 14-10-25 19:45 | 14-10-25 19:45 | Toulouse | IFK Kristianstad | 28:30 | 2 - 17 pontos |