Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 11-09-21 12:30 | 11-09-21 12:30 | Crystal Palace | Tottenham Hotspurs | 3:0 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | Brentford FC | Brighton and Hove Albion | 0:1 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | Leicester City | Manchester City | 0:1 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | Manchester United | Newcastle United | 4:1 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | FC Southampton | West Ham United | 0:0 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | FC Arsenal | Norwich City | 1:0 | 2 - 5 pontos |
| 11-09-21 15:00 | 11-09-21 15:00 | FC Watford | Wolverhampton Wanderers | 0:2 | 2 - 5 pontos |
| 11-09-21 17:30 | 11-09-21 17:30 | FC Chelsea | Aston Villa | 3:0 | 2 - 5 pontos |
| 12-09-21 16:30 | 12-09-21 16:30 | Leeds United | FC Liverpool | 0:3 | 2 - 5 pontos |
| 13-09-21 20:00 | 13-09-21 20:00 | FC Everton | FC Burnley | 3:1 | 2 - 5 pontos |