Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25-09-21 16:00 | 25-09-21 16:00 | AS St. Etienne | OGC Nice | 0:3 | 2 - 5 pontos |
| 25-09-21 18:00 | 25-09-21 18:00 | Racing Club Estrasburgo | OSC Lille | 1:2 | 2 - 5 pontos |
| 25-09-21 20:00 | 25-09-21 20:00 | Olympique Lyon | FC Lorient | 1:1 | 2 - 5 pontos |
| 25-09-21 20:00 | 25-09-21 20:00 | Paris St. Germain | HSC Montpellier | 2:0 | 2 - 5 pontos |
| 26-09-21 12:00 | 26-09-21 12:00 | Girondins Bordeaux | Stade Rennes | 1:1 | 2 - 5 pontos |
| 26-09-21 14:00 | 26-09-21 14:00 | ES Troyes AC | SCO Angers | 1:1 | 2 - 5 pontos |
| 26-09-21 14:00 | 26-09-21 14:00 | Stade Brest 29 | FC Metz | 1:2 | 2 - 5 pontos |
| 26-09-21 14:00 | 26-09-21 14:00 | Stade Reims | FC Nantes | 3:1 | 2 - 5 pontos |
| 26-09-21 16:05 | 26-09-21 16:05 | Clermont Foot | AS Mónaco | 1:3 | 2 - 5 pontos |
| 26-09-21 19:45 | 26-09-21 19:45 | Olympique Marselha | RC Lens | 2:3 | 2 - 5 pontos |