Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Grupo | Resultado | Regra de pontuação |
|---|---|---|---|---|---|---|
| 02-11-21 17:45 | 02-11-21 17:45 | Malmö FF | FC Chelsea | Grupo H | 0:1 | 6 - 6 - 3 |
| 02-11-21 17:45 | 02-11-21 17:45 | VfL Wolfsburgo | FC Red Bull Salzburgo | Grupo G | 2:1 | 4 - 5 - 4 |
| 02-11-21 20:00 | 02-11-21 20:00 | Juventus Turim | Zenit S.Petersburgo | Grupo H | 4:2 | 3 - 6 - 6 |
| 02-11-21 20:00 | 02-11-21 20:00 | FC Sevilla | OSC Lille | Grupo G | 1:2 | 3 - 6 - 6 |
| 02-11-21 20:00 | 02-11-21 20:00 | FC Bayern Munique | Benfica | Grupo E | 5:2 | 3 - 6 - 6 |
| 02-11-21 20:00 | 02-11-21 20:00 | Dínamo Kiev | FC Barcelona | Grupo E | 0:1 | 6 - 4 - 3 |
| 02-11-21 20:00 | 02-11-21 20:00 | Atalanta Bergamo | Manchester United | Grupo F | 2:2 | 6 - 5 - 3 |
| 02-11-21 20:00 | 02-11-21 20:00 | FC Villarreal | Young Boys Berna | Grupo F | 2:0 | 3 - 6 - 6 |
| 03-11-21 17:45 | 03-11-21 17:45 | Real Madrid | Shaktiar Donetsk | Grupo D | 2:1 | 3 - 6 - 6 |
| 03-11-21 17:45 | 03-11-21 17:45 | AC Milão | FC Porto | Grupo B | 1:1 | 3 - 6 - 6 |
| 03-11-21 20:00 | 03-11-21 20:00 | Sheriff Tiraspol | Inter Milão | Grupo D | 1:3 | 6 - 6 - 3 |
| 03-11-21 20:00 | 03-11-21 20:00 | FC Liverpool | Atlético Madrid | Grupo B | 2:0 | 3 - 6 - 6 |
| 03-11-21 20:00 | 03-11-21 20:00 | Manchester City | FC Brugges | Grupo A | 4:1 | 3 - 6 - 6 |
| 03-11-21 20:00 | 03-11-21 20:00 | RB Leipzig | Paris St. Germain | Grupo A | 2:2 | 6 - 6 - 3 |
| 03-11-21 20:00 | 03-11-21 20:00 | Sporting | Besiktas Istambul | Grupo C | 4:0 | 3 - 6 - 6 |
| 03-11-21 20:00 | 03-11-21 20:00 | Borussia Dortmund | Ajax Amsterdão | Grupo C | 1:3 | 4 - 4 - 4 |