Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 22-10-21 19:30 | 22-10-21 19:30 | FSV Mainz 05 | FC Augsburg | 4:1 | 3 - 6 - 6 |
| 23-10-21 14:30 | 23-10-21 14:30 | RB Leipzig | SpVgg Greuther Fürth | 4:1 | 3 - 6 - 6 |
| 23-10-21 14:30 | 23-10-21 14:30 | FC Bayern Munique | 1899 Hoffenheim | 4:0 | 3 - 6 - 6 |
| 23-10-21 14:30 | 23-10-21 14:30 | Arminia Bielefeld | Borussia Dortmund | 1:3 | 6 - 6 - 3 |
| 23-10-21 14:30 | 23-10-21 14:30 | VfL Wolfsburgo | SC Friburgo | 0:2 | 6 - 3 - 6 |
| 23-10-21 17:30 | 23-10-21 17:30 | Hertha BSC Berlim | Bor. Mönchengladbach | 1:0 | 6 - 5 - 3 |
| 24-10-21 14:30 | 24-10-21 14:30 | 1. FC Colónia | Bayer 04 Leverkusen | 2:2 | 6 - 6 - 3 |
| 24-10-21 16:30 | 24-10-21 16:30 | VfB Estugarda | 1. FC Union Berlim | 1:1 | 5 - 4 - 4 |
| 24-10-21 18:30 | 24-10-21 18:30 | VfL Bochum | Eintracht Frankfurt | 2:0 | 6 - 4 - 4 |